Salvia Miltiorrhiza, commonly known as Danshen or Red Sage, is a traditional Chinese medicinal herb. The root extract of Salvia Miltiorrhiza is particularly noted for containing Tanshinone IIA, one of its most potent bioactive compounds. Tanshinone IIA is a major lipophilic component that contributes to the wide-ranging health benefits of this plant, especially in cardiovascular and anti-inflammatory contexts.
Key Characteristics
Source: The extract is derived from the root of the Salvia Miltiorrhiza plant, native to China and Japan. This herb has been used for centuries in traditional Chinese medicine to treat cardiovascular diseases, liver disorders, and inflammation.
Form: Available as a concentrated extract in powder or liquid form, and often standardized to contain a high percentage of Tanshinone IIA.
Bioactive Compound: Tanshinone IIA is a diterpene quinone, recognized for its powerful pharmacological effects, particularly in promoting heart health and reducing inflammation.
Active Substances and Their Specific Effects
1. Tanshinone IIA
Tanshinone IIA is the primary active constituent in Salvia Miltiorrhiza extract. It exhibits a wide array of therapeutic effects:
Cardiovascular Protection:
Anti-Atherosclerotic: Inhibits the formation of plaques in the arteries, thereby preventing atherosclerosis.
Improves Blood Flow: Enhances endothelial function and increases nitric oxide production, leading to vasodilation and improved blood flow.
Reduces Hypertension: Helps in lowering high blood pressure through its vasodilatory effects.
Anti-Inflammatory Effects:
Inhibition of Inflammatory Pathways: Reduces the production of pro-inflammatory cytokines and inhibits NF-κB signaling, a key regulator in the inflammatory response.
Arthritis Relief: Alleviates symptoms of inflammatory joint diseases like arthritis by reducing swelling and pain.
Antioxidant Activity:
Free Radical Scavenging: Protects cells from oxidative damage by neutralizing free radicals and enhancing cellular antioxidant defenses.
Prevention of Oxidative Stress: Mitigates oxidative stress, which is implicated in various chronic diseases, including heart disease and cancer.
Anti-Cancer Properties:
Tumor Growth Inhibition: Induces apoptosis (programmed cell death) in cancer cells and inhibits their proliferation.
Metastasis Prevention: Prevents the spread of cancer cells to other parts of the body by interfering with cellular pathways involved in metastasis.
Neuroprotective Effects:
Cognitive Health: Protects neurons from oxidative stress and inflammation, potentially reducing the risk of neurodegenerative diseases like Alzheimer's.
Stroke Prevention: Reduces the risk of ischemic strokes by improving cerebral blood flow and protecting brain cells from damage.
Liver Health:
Hepatoprotective: Shields liver cells from damage caused by toxins and oxidative stress.
Enhances Detoxification: Promotes the liver's detoxification processes, improving overall liver function.
2. Other Bioactive Compounds
In addition to Tanshinone IIA, Salvia Miltiorrhiza contains various other compounds that contribute to its medicinal properties, including:
Danshensu: Provides antioxidant and anti-inflammatory benefits.
Salvianolic Acids: Exhibit strong antioxidant properties and protect against cardiovascular diseases.
Applications
1. Dietary Supplements:
Cardiovascular Health: Formulated into supplements aimed at promoting heart health, improving circulation, and managing blood pressure.
Anti-Inflammatory Products: Included in products designed to reduce inflammation and alleviate symptoms of chronic inflammatory conditions.
2. Pharmaceuticals:
Heart Medications: Used in traditional and modern formulations for the prevention and treatment of heart diseases.
Cancer Therapies: Investigated for its potential in adjunctive cancer therapy due to its anti-cancer properties.
3. Cosmetic Products:
Anti-Aging Creams: Incorporated into skincare products for its antioxidant properties and ability to protect against skin aging.
Skin Health: Utilized in treatments aimed at reducing inflammation and promoting skin healing.
4. Traditional Medicine:
Herbal Teas: Brewed as a tea or decoction for its calming effects and to support cardiovascular health.
Poultices and Tinctures: Used in traditional applications to relieve pain and reduce inflammation.
In addition to the sale of Herbal Extract, our company can provide OEM&ODM. If you do not find the product you need on our website, please tell me. We would like to be your buyer in China, and we will do our best to purchase the products you need.
